Harlan TD.00158 維生素A缺乏飲食 Vitamin A Deficient Diet

貨號：TD.00158

英文名稱：Vitamin A Deficient Diet

Footnote
This modification of diet AIN-93G (TD 94045) omits vitamin A palmitate and
substitutes alcohol-extracted casein for regular casein. Diet should contain
less than 20 IU vitamin AVkg diet.

Selected Nutrient Information

Key Features
+ Purified Diet
+ Vitamin A
+ VFT Casein
+ AIN-93G Modification

Key Planning Information
+ Products are made fresh to order
+ Store product at 4°C or lower? ?將產品存放在4°C或更低的溫度下

+Use within 6 months (applicable to most diets)
+ Box labeled with product name,
manufacturing date, and lot number
+ Replace diet at minimum once per week
More frequent replacement may be advised

+ Lead time:
2 weeks non-irradiated
4 weeks irradiated

Product Specific Information
1/2”Peilet of Powder (free flowing)? 1/2”粉餅（自由流動）
+ Minimum order 3 Kg
+ Irradiation not advisea
Contact a nutntionist for recommendations

Harlan Teklad 動物飼料 Vitamin A Diet(25,000)成分表

Harlan Teklad動物飼料
Harlan代理–上海金畔生物科技有限公司
歡迎新老客戶訪問Harlan官網或者咨詢中國代理商上海金畔生物獲取更多詳細資料。

Foothote

This modification of diet AIN-93G (TD.94045) replaces vitamin A palmitate with
tamin A acetate and increases the total concentration to approximately 25,000
/kg. Alcohol-extracted casein is substituted for regular casein.

Selected Nutrient Information

Values are calculated from ingredient analysis or manufacturer data

Key Features

+ Purifield? ?Diet
+Vitamin A
+AlN 93G Modification
+ Rodent

Key Planning Information

+ Product are made Fresh fo order
+ store product at 4° C or IoWer
+ Use within 6 months(appIicable to most diets)
+ Box Labeled with product name
manufaGturing date,and Iot number
+ Replace diet at nninimunη once per weekation

Harlan動物飼料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 成分表

Harlan Teklad動物飼料
Harlan代理–上海金畔生物科技有限公司
歡迎新老客戶訪問Harlan官網或者咨詢中國代理商上海金畔生物獲取更多詳細資料。

嚙齒動物飼料（2018，625強力霉素）

Footnote? ?Harlan動物飼料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 使用說明

This diet was designed to deliver a daily dose of 2-3 mg of doxycycline based on consumption of 4-5 g/d by a mouse. Doxycycline hyclate contains approximately 87% doxycycline.

這種飲食被設計為以小鼠每天4-5 g / d的消耗量提供2-3 mg強力霉素的日劑量。 鹽酸多西環素含有約87％的多西環素。

Selected Nutrient Information

• Values are calculated from ingredient analysis or manufacturer data

• Estimated digestible carbohydrate

Key Features

• Standard Diet Base
• Doxycycline
• Gene Induction
• 2018

Key Planning Information

• Products are made fresh to order
• Store product at 4°C or lower
• Use within 6 months (applicable to most diets)
• Box labeled with product name, manufacturing date, and lot number
• Replace diet at minimum once per week

More frequent replacement may be advised

• Lead time:
• 2 weeks non-irradiated
• 4 weeks irradiated

Product Specific Information

• 1/2″ Pellet or Powder (free flowing)
• Minimum order 3 Kg
• Irradiation available upon request

Harlan Teklad Diet ingredients

Teklad diet, bedding and enrichment?+?Teklad laboratory animal diets?+?Custom research diets?+?Diet ingredients

You may want to prepare your own diet at your research site or facility, and if that is the case, you depend on the ingredients being of the highest quality. Envigo can provide you with many of the same ingredients used to produce our advanced Teklad custom research diets so you can develop your own formula. And as always, our nutritional experts are here to help you make the best decisions for your ingredients and ultimate formulation.

Our ingredients

We offer several?ingredients?for individual sale so that you can develop your own blends.

“VFT” casein

• “Vitamin-free” test casein?(alcohol-extracted) is best suited for purified test diet formulas where fat or vitamin content needs to be precisely controlled
• The reduced levels of many vitamins in VFT casein make it the preferred protein source for many vitamin studies. Thus, the nickname “Vitamin-free” was given to the extracted casein many years ago

Vitamin mixes

• The common vitamin mixes shown below use sucrose or corn starch as a carrier
• Customized vitamin mixes may use cellulose if a non-nutritive carrier is necessary
• Vitamin mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of your laboratory animal
• For those preparing their own diets, vitamin premixes are an efficient way to add vitamins to a diet
• Vitamin mixes should be stored at 4 degrees celsius or lower upon receipt. Storage at –20 degrees celsius is recommended if the mix will be used beyond 1 month
• Minimum order is 500 g for both stock and custom vitamin mixes
• Our available vitamin mixes are commonly used in diets, and are available from stock
• Vitamin mixes are shipped within a few days of order

Our Formula examples

• CA.40060?Teklad vitamin mix
• CA.40077?AIN-76A vitamin mix
• TD.94047?AIN-93 vitamin mix

Mineral mixes

• The common mineral mixes shown below as examples use sucrose as a carrier
• Customized mineral mixes could use cellulose or no carrier if a non-nutritive carrier is necessary
• Our mineral mixes are formulated with a diet inclusion rate in mind. Using more or less than recommended could impair the health of the animal
• For those preparing their own diets, mineral premixes are an efficient way to add minerals to a diet
• Mineral mixes should be stored in a dry cool environment and used within a year of receipt. The minimum order is 500 g for both stock and custom mineral mixes
• These mineral mixes are commonly used in diets, and are available from stock
• Our mineral mixes are shipped within a few days of order

Formula examples:

• CA.170915?AIN-76 mineral mix
• TD.94046?AIN-93G mineral mix
• TD.94049?AIN-93M mineral mix

Other mixes (may or may not be available from stock):

• TD.83171?Vitamin mix without A, D, E, choline
• TD.81062?Iron deficient mineral mix based on AIN-76A
• TD.79055?Calcium and phosphorus deficient mineral mixed based on AIN-76
• TD.98057?Calcium and phosphorus deficient mineral mixed based on AIN-93
• CA.170760?Rogers-Harper mineral mix

你可能想要在你的研究地點或設施準備你自己的飲食，如果是這樣的話，你取決于成分是最高的質量。Envigo可以為您提供許多相同的成分，用于生產我們先進的特克拉德定制研究飲食，以便您可以開發自己的配方。和往常一樣，我們的營養專家在這里幫助您為您的配料和最終配方做出佳決定。

我們的配料

我們提供幾個配料供個人銷售，以便您可以開發自己的混合。

“VFT”酪蛋白

• “無維生素”測試酪蛋白(酒精提取)最適合于那些需要精確控制脂肪或維生素含量的純正試驗飲食配方。
• VFT酪蛋白中許多維生素含量的降低使得它成為許多維生素研究的首選蛋白質來源。因此，“無維生素”的綽號是在許多年前給提取出來的酪蛋白起的。

維生素混合物

• 以下常見的維生素混合物使用蔗糖或玉米淀粉作為載體。
• 定制的維生素混合物可能使用纖維素，如果非營養載體是必要的。
• 維生素混合物的制定考慮到了飲食中的包容率。多用或少用會損害你的實驗動物的健康。
• 對于那些自己準備飲食的人來說，維生素預混劑是向飲食中添加維生素的一種有效方法。
• 維生素混合物應儲存在4攝氏度或更低的接收。如果使用時間超過1個月，建議使用攝氏-20度。
• 庫存和定制維生素混合物的最低訂購量為500克。
• 我們可用的維生素混合物通常用于飲食，并可從庫存中獲得。
• 維生素混合物在訂購后幾天內發貨。

我們的公式示例

• CA.40060 特克拉德維生素混合物
• CA.40077 AIN-76A維生素混合物
• TD.94047 AIN-93維生素混合物

礦物混合物

• 下面所示的常見礦物混合物是以蔗糖為載體的。
• 如果需要非營養的載體，定制的礦物混合物可以使用纖維素，也可以不使用載體。
• 我們的礦物質混合物是根據飲食包容率來制定的。多用或少用會損害動物的健康。
• 對于那些自己準備飲食的人來說，礦物預混料是向飲食中添加礦物質的有效方法。
• 礦物混合物應存放在干燥、涼爽的環境中，并在收到后一年內使用。庫存和自定義礦物混合物的最低訂購量為500克。
• 這些礦物混合物通常用于飲食，并可從庫存中獲得。
• 我們的礦物混合物在訂貨后幾天內裝運。

公式示例：

• CA.170915 AIN-76礦物混合物
• TD.94046 AIN-93g礦物混合物
• TD.94049 AIN-9300萬礦物混合物

其他混合材料(可能從庫存中獲得，也可能無法從庫存中獲得)：

• TD.83171不含A，D，E，膽堿的維生素混合物
• TD.81062基于AIN-76A的缺鐵礦物配料
• TD.79055?AIN-76混合鈣磷缺乏礦物
• TD.98057AIN-93混合鈣磷缺乏礦物
• CA.170760 羅杰斯-哈珀礦物混合物

Harlan Teklad 2016 global 16% protein rodent diets

Product Features

• Designed to support growth and maintenance
• Formulated to exclude soybean meal, thus minimizing the presence of isoflavones, the primary type of?phytoestrogen?found in lab animal diets
• Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from non-detectable to 20 mg/kg
• Exclusion of alfalfa reduces chlorophyll, greatly improving?fluorescent optical imagingclarity
• Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)

Teklad Global 16% Protein Rodent Diet

Product Description- 2016 is a fixed formula, non-autoclavable diet
manufactured with high quality ingredients and designed to support growth
and maintenance. 2016 does not contain alfalfa or soybean meal, thus
minimizing the occurrence of natural phytoestrogens. Typical isoflavone
concentrations (daidzein + genistein aglycone equivalents) range from nondetectable
to 20 mg/kg. Exclusion of alfalfa reduces chlorophyll, improving
optical imaging clarity. Absence of animal protein and fish meal minimizes
the presence of nitrosamines. Also available certified (2016C) and
irradiated (2916). For autoclavable diet, refer to 2016S (Sterilizable).

Macronutrients

Teklad Diets are designed and manufactured for research purposes only.

Ingredients (in descending order of inclusion)- Ground wheat, ground corn,?wheat middlings, corn gluten meal, calcium carbonate, dicalcium phosphate, soybean oil, brewers dried yeast, iodized salt, L-lysine, DL-methionine, choline chloride, magnesium oxide, vitamin E acetate, menadione sodium bisulfite complex (source of vitamin K activity), manganous oxide, ferrous sulfate, zinc oxide, niacin, calcium pantothenate, copper sulfate, pyridoxine hydrochloride, riboflavin, thiamin mononitrate, vitamin A acetate, calcium iodate, vitamin B₁₂?supplement, folic acid, biotin, vitamin D₃?supplement,

cobalt carbonate.

Vitamins

• Ether extract is used to measure fat in pelleted diets, while an acid hydrolysis method is required to recover fat in extruded diets. Compared to ether extract, the fat value for acid hydrolysis will be approximately 1% point higher.

• Carbohydrate (available) is calculated by subtracting neutral detergent fiber from total carbohydrates.

• Neutral detergent fiber is an estimate of insoluble fiber, including cellulose, hemicellulose, and lignin. Crude fiber methodology underestimates total fiber.

• Energy density is a calculated estimate of metabolizable energybased on the Atwater factors assigning 4 kcal/g to protein, 9 kcal/g to fat, and 4 kcal/g to available carbohydrate.

• Indicates added amount but does not account for contribution from other ingredients.

• 1 IU vitamin A = 0.3 μg retinol

• 1 IU vitamin D = 25 ng cholecalciferol

For nutrients not listed, insufficient data is available to quantify.

Nutrient data represent the best information available, calculated from published values and direct analytical testing of raw materials and finished product. Nutrient values may vary due to the natural variations in the ingredients, analysis, and effects of processing.

Harlan 嚙齒類飼料 Rodent diets

As a researcher, you want to have as much control as possible over what goes into your study animals. At Envigo, we understand that. That is why we developed?Teklad Global Rodent Diets?.

Teklad Global Rodent Diets??are a special integrated range of vegetarian laboratory rodent diets developed to be nutritionally complete for various life stages from breeding through long-term maintenance. Global rodent laboratory diets contain levels of protein, energy, vitamins and minerals that are more appropriate to the needs of modern biomedical research studies.

Furthermore, in global rodent diets particular attention has been placed on avoiding, as far as practical, ingredients that are reported to have adverse confounding effects on experimental results. This has resulted in a range of Teklad rodent laboratory diets that contain:

No fish meal

No meat meals or meat by-products

No alfalfa meal

No soybean meal or reduced levels

No animal fat

By excluding animal by-products, the presence of nitrosamines (a potential carcinogen) is avoided. Exclusion of alfalfa meal reduces chlorophyll, improving optical imaging clarity. Reduction or removal of soybean meal, together with elimination of alfalfa meal, minimizes levels of naturally-occurring phytoestrogens. Phytoestrogens interact with endogenous estrogens and potentially can affect studies in many?research areas. Read more about this in these pieces:

Dietary phytoestrogens, a source of research variation
Ask a Nutritionist Series: Impact of phytoestrogens on research, Volume 1

Phytoestrogens limit translation of preclinical results to clinical outcomes
Ask a Nutritionist Series: Impact of phytoestrogens on research, Volume 2

Harlan TD.88137 高酯飼料Adjusted calories diet (42% from fat)說明書

Harlan Teklad代理，歡迎訪問Harlan Teklad官網或者咨詢我們獲取更多相關產品信息。

A staple of atherosclerosis research

More than 25 years ago, our nutritionists collaborated with researchers at Rockefeller University to develop a diet with features of a ‘Western Diet’ to characterize and enhance atherosclerosis development in their newly generated Apoe?deficient mouse model.

With over 200 unique users worldwide, TD.88137 continues to be fed to genetically modified cardiovascular models to accelerate and enhance hypercholesterolemia and plaque formation.

Selected nutrient information1

• Values are calculated from ingredient analysis or manufacturer data.
• 15% added, 0.05% from fat source.

Critical dietary features of TD.88137 related to atherosclerosis development include:

++Cholesterol (0.2% total cholesterol)

++Total fat (21% by weight; 42% kcal from fat)

++High in saturated fatty acids

(>60% of total fatty acids)

++High sucrose (34% by weight)

Typical fatty acid profile of TD.88137

• n = 21, analysis conducted by two independent laboratories.
• Unidentified fatty acids and those contributing on average less than 0.5% of total fatty acids.
• Includes trans isomers elaidic and vaccenic acid and unidentified cis isomers.
• Includes trans isomers.

Key points from the literature

TD.88137 has been used to accelerate atherosclerosis development in Apoe?and Ldlr?deficient models:

++In?Apoe?deficient mice, plasma cholesterol triples?to >1500 mg/dL within three weeks (1, 2). Foam cell and lesion development occurs within 6-10 weeks (2-4). Fibrous plaque formation is observed at 15 weeks with the development of fibrous caps after 20 weeks (2).

++Ldlr?deficient mice fed for two weeks increase?plasma cholesterol to >800 mg/dL and triglyceride to >300 mg/dL (5). After six weeks of feeding, hyperglycemia, hyperinsulinemia and dyslipidemia develop with small foam cell lesions in the aortic arch (6, 7).

For further information about TD.88137, or if you are interested in learning more about other atherogenic or high fat diets contact us at

With over 420 citations, uses of TD.88137 continue to evolve and include atherosclerosis, obesity, non-alcoholic steatohepatitis (NASH), osteoporosis, hypertension and metabolic syndrome. Contact us for a more extensive reference list.

Control diet options for TD.88137

Natural ingredient diets

++Also referred to as standard diets or chow

++Diets differ in the source and level of nutrients?as well as the presence of non-nutritive factors (such as phytates or phytoestrogens) compared to TD.88137

++Limits inferences to differences in dietary pattern?versus a specific dietary component

Ingredient matched, low fat diets

++Controls for the type of ingredients, non-nutritive?components and the source and level of specific nutrients

++Suggested ingredient matched, low fat dietary?controls for TD.88137 listed below; data sheets can be found on our website at

Suggested ingredient matched, low fat controls

Additional controls are available. Contact a nutritionist at

Key planning information:

• Store diet refrigerated and plan to use within six months. Diet should be replaced at minimum once per week when fed on cage tops.
• Diets available as a soft ?” pellet or as a crumbly powder.
• Three kg minimum order quantity. For planning purposes, estimates for diet uses (including feed intake and diet waste) are 5 g of diet per mouse and 30 g of diet per rat per day.
• Two-day lead time for orders less than 10 kg. Two-week lead time for larger quantity orders.
• Lead time for irradiation adds two weeks for any quantity of diet and must be requested at the time you place your order. Changes in texture and browning may occur with irradiation.
• Shipping can affect pellet quality. Vacuum packaging can offer protection of the pellets during shipping. Two-day shipping is recommended during warmer months.

Contact us to place an order,

References

1. Plump, A.S., et al.,Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell, 1992. 71(2): p. 343-53.
2. Nakashima, Y., et al.,Apoe-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb, 1994.?14(1): p. 133-40.
3. Febbraio, M., et al.,Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.

J Clin Invest, 2000. 105(8): p. 1049-56.

4. Nakashima, Y., et al.,Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the Apoe-deficient mouse. Arterioscler Thromb

Vasc Biol, 1998. 18(5): p. 842-51.

5. Towler, D.A., et al.,Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice.

J Biol Chem, 1998. 273(46): p. 30427-34.

6. Tsuchiya, K., et al.,FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab, 2012. 15(3): p. 372-81.
7. Huszar, D., et al.,Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1. Arterioscler?Thromb Vasc Biol, 2000. 20(4): p. 1068-73.
8. Yang, B., et al.,Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats. Biochem Biophys Res Commun, 2006. 341(1): p. 209-17.
9. Schafer, K., et al.,Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc Biol, 2004. 24(1): p. 112-7.
10. Lijnen, H.R., et al.,Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1. Arterioscler Thromb Vasc?Biol, 2003. 23(1): p. 78-84.
11. Maquoi, E., et al.,Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes, 2002.?51(4): p. 1093-101.
12. VanSaun MN, et al. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol 175:355-64.
13. Dixon LJ, et al. Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One 8:e56100.